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The over-expression and lack of control of cell reproduction, mediated by the family of epidermal growth factor receptors (at cell membrane level), is now regarded as important in the progressive growth of many carcinomas.

A recent clinical trial with 'pertuzumab' an inhibitor of EGFR has unfortunately failed to show clinical responses in patients with hormone resistane prostate cancer - according to a trial reported in the Journal of Clinical Oncology from a multi-institutional group in the USA